1,9. Rejection calculated based on cumulative submissions of PVS and iTero scans from Jan 2017 to June 2018. data on file at Align Technology, as of July 2018. 
2,4,6. compared to  Invisalign aligners previously made from single-layer (EX30) material.  aligners made from SmartTrack material provide better fit, better comfort, and are easier to insert and remove compared to Invisalign aligners made from single-layer  (EX30) material. **In a study Miller et al, with adults measuring pain in the first week of treatment. Kevin Miller et al.  “A comparison of treatment impacts between Invisalign aligner and fixed appliance therapy during the first week of treatment.”  American Journal of Orthodontics and Dentofacial Orthopedics.  Volume 131, Issue 3, pp. 302. e1-302.e9, March 2007.”
3. Gu, J et al. Evaluation of Invisalign Treatment effectiveness and efficiency compared with conventional fixed appliances using the Peer Assessment Rating index. Am J Orthod Dentofacial Orthop February 2017, 151 259-66. Buschang, P et al Comparative time efficiency of aligner therapy and conventional edgewise braces. Angle Orthodontist, Vol 84, No 3, 2014.
5. Data on file at Align Technology, as of October 2020.
7. Some Providers still take physical impressions using soft putty. These impressions are then scanned by Invisalign technicians to create the 3D image for use in the ClinCheck software and manufacturing aligners.
8. Data on file at Align Technology, as of November 7th, 2018.
10. Data on file at Align Technology, as of October 12, 2017.
11. With weekly aligner changes, compared with two-week aligner changes.